Saccharomyces boulardii CNCM I-745 was discovered in 1923² when a French microbiologist visiting South East Asia noticed that locals who drank a concoction made from the skins of mangosteens and lychees did not develop diarrhea.¹ It was from the skins of these fruits that he isolated the unique yeast strain Saccharomyces boulardii CNCM I-745¹.

S. boulardii CNCM I-745 gastrointestinal benefits can be directly linked to this specific yeast and its mechanisms of action.^1,3,4  This one single yeast can act on harmful bacteria, help gut cells to grow and function normally. In addition, the yeast has anti-inflammatory activity which not only reduces diarrhea, but also promotes restoration of beneficial microbiota.² Finally, unlike bacterial probiotics, S. boulardii CNCM I-745 is naturally resistant to antibiotics so it can be taken at the same time as antibiotics.⁵

This unique Saccharomyces boulardii CNCM I-745 yeast has proven efficacy to address multiple gastrointestinal disorders associated with diarrhea including acute diarrhea, antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea.³ Furthermore, S. boulardii has been shown to reduce gastrointestinal side effects associated with Helicobacter pylori eradication therapy⁷,  as well as induce the rapid recovery of normal beneficial microbiota following a microbiota disturbance.²

Saccharomyces boulardii CNCM I-745 is preserved using a unique lyophilisation process that freeze-dries the yeast to preserve vitality and viability.¹ This manufacturing site is the largest lyophilisation facility in the world!

The unique lyophilisation process means that S. boulardii CNCM I-745 survives the whole manufacturing process (including packaging, storage and transportation), as well its journey through the stomach to the intestine.² Thus ensuring the viability of the probiotic so that it can act to address the symptoms and causes of diarrhea and microbiota imbalance.^1,2