Frequently Asked Questions

What is Saccharomyces boulardii CNCM I-745 ?
  • Is Saccharomyces boulardii CNCM I-745 a probiotic?
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  • Is Saccharomyces boulardii CNCM I-745 a living organism?
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  • What is the name of the product in my country?
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Practical information on Saccharomyces boulardii CNCM I-745
  • What can Saccharomyces boulardii CNCM I-745 be used for?
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  • Is it relevant to combine Saccharomyces boulardii CNCM I-745 with antibiotics?
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  • Is Saccharomyces boulardii CNCM I-745 suitable for children?
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Gut flora and gastrointestinal health
  • What factors can influence my microbiota?
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  • How do antibiotics impact my gut microbiota?
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  • Why are probiotics good for my gut flora?
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Saccharomyces boulardii CNCM I-745, a scientifically proven effective probiotic
  • Why Saccharomyces boulardii CNCM I-745 is efficient?
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  • How does Saccharomyces boulardii CNCM I-745 work and how is it adapted to address diarrhea?
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  • Is Saccharomyces boulardii CNCM I-745 recommended by international gastroenterology societies?
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Internal code : 20.59

References

  • 01 . Moré MI, Swidsinski A. Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis – A review. Clinical and Experimental Gastroenterology. 2015;8:237-255. doi:10.2147/CEG.S85574
  • 02 . Guarner F, Sanders M, Eliakim R, et al. Probiotics and prebiotics. World Gastroenterology Organisation Global Guidelines. 2017:1-35. https://www.worldgastroenterology.org/guidelines/global-guidelines/probiotics-and-prebiotics/probiotics-and-prebiotics-english.
  • 03 . Joly F, Nuzzo A, Czeruchka D. Saccharomyces boulardii CNCM I-745. In: Marteau P, Dore J, eds. Gut Microbiota: A Full-Fledged Organ. Paris: John Libbey Eurotext; 2017:305-350.
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  • 04 . Based on PubMed search. https://www.ncbi.nlm.nih.gov/pubmed, search term “boulardii.”
  • 05 . Kolaček S, Hojsak I, Berni Canani R, et al. Commercial Probiotic Products: A Call for Improved Quality Control. A Position Paper by the ESPGHAN Working Group for Probiotics and Prebiotics. Journal of Pediatric Gastroenterology and Nutrition. 2017;65(1):117-124. doi:10.1097/MPG.0000000000001603
  • 06 . Hill C, Guarner F, Reid G, et al. Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology and Hepatology. 2014;11(8):506-514. doi:10.1038/nrgastro.2014.66
  • 07 . Sanders ME, Klaenhammer TR, Ouwehand AC, et al. Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics. Annals of the New York Academy of Sciences. 2014;1309(1):1-18. doi:10.1111/nyas.12363
  • 08 . Szajewska H, Canani RB, Guarino A, et al. Probiotics for the prevention of antibiotic-associated diarrhea in children. Journal of Pediatric Gastroenterology and Nutrition. 2016;62(3):495-506. doi:10.1097/MPG.0000000000001081
  • 09 . Cameron D, Hock QS, Kadim M, et al. Probiotics for gastrointestinal disorders: Proposed Recommendations for children of the Asia-Pacific region. World Journal of Gastroenterology. 2017;23(45):7952-7964. doi:10.3748/wjg.v23.i45.7952
  • 10 . Ghoshal UC, Gwee KA, Holtmann G, et al. The role of the microbiome and the use of probiotics in gastrointestinal disorders in adults in the Asia-Pacific region – background and recommendations of a regional consensus meeting. Journal of Gastroenterology and Hepatology (Australia). 2018;33(1):57-69. doi:10.1111/jgh.13840
  • 11 . Cruchet S, Furnes R, Maruy A, et al. The Use of Probiotics in Pediatric Gastroenterology: A Review of the Literature and Recommendations by Latin-American Experts. Pediatric Drugs. 2015;17(3):199-216. doi:10.1007/s40272-015-0124-6
  • 12 . Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H. European society for pediatric gastroenterology, hepatology, and nutrition/european society for pediatric infectious diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: Update 2014. Journal of Pediatric Gastroenterology and Nutrition. 2014;59(1):132-152. doi:10.1097/MPG.0000000000000375
  • 13 . Malfertheiner P, Megraud F, O’Morain C, et al. Management of helicobacter pylori infection-the Maastricht V/Florence consensus report. Gut. 2017;66(1):6-30. doi:10.1136/gutjnl-2016-312288
  • 14 . S. boulardii CNCM I-745 Summary of Product Characteristics.
  • 15 . McFarland L V. Systematic review and meta-analysis of saccharomyces boulardii in adult patients. World Journal of Gastroenterology. 2010;16(18):2202-2222. doi:10.3748/wjg.v16.i18.2202
  • 16 . McFarland L V. Epidemiology, Risk Factors and Treatments for Antibiotic-Associated Diarrhea. Digestive Diseases. 1999;16(5):292-307. doi:10.1159/000016879
  • 17 . Francino MP. Antibiotics and the human gut microbiome: Dysbioses and accumulation of resistances. Frontiers in Microbiology. 2016;6(JAN):1-11. doi:10.3389/fmicb.2015.01543
  • 18 . Panda S, El Khader I, Casellas F, et al. Short-term effect of antibiotics on human gut microbiota. PLoS ONE. 2014;9(4). doi:10.1371/journal.pone.0095476
  • 19 . Palleja A, Mikkelsen KH, Forslund SK, et al. Recovery of gut microbiota of healthy adults following antibiotic exposure. Nature Microbiology. 2018;3(11):1255-1265. doi:10.1038/s41564-018-0257-9
  • 20 . Neut C, Mahieux S, Dubreuil LJ. Antibiotic susceptibility of probiotic strains: Is it reasonable to combine probiotics with antibiotics? Medecine et Maladies Infectieuses. 2017;47(7):477-483. doi:10.1016/j.medmal.2017.07.001
  • 21 . Butel MJ, Waligora-Dupriet AJ, Wydau-Dematteis S. The developing gut microbiota and its consequences for health. Journal of Developmental Origins of Health and Disease. 2018;9(6):590-597. doi:10.1017/S2040174418000119
  • 22 . Butel M, Lepage P, Collignon A. Microbiota development: from the in utero period to the first few years of life. In: Marteau P, Dore J, eds. Gut Microbiota: A Full-Fledged Organ. Paris: John Libbey Eurotext; 2017:25-34.
  • 23 . McFarland L V. Antibiotic-associated diarrhea: Epidemiology, trends and treatment. Future Microbiology. 2008;3(5):563-578. doi:10.2217/17460913.3.5.563
  • 24 . Czerucka D, Rampal P. Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections. World journal of gastroenterology. 2019;25(18):2188-2203. doi:10.3748/wjg.v25.i18.2188
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